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Research Topics: innate immunity, lung inflammation, infection biology
Brief Scientific Description:
Work in our laboratory centers on the metabolic programs that contribute to neutrophil biology in health and disease. Neutrophils rely primarily on glycolysis for energy production but it is increasingly recognized that mitochondrial metabolic programs contribute to many neutrophil effector functions. We are currently focused on mitochondrial beta-oxidation of long chain fatty acids, as this metabolic program is essential for optimal neutrophil chemotaxis and trafficking to the site of infection in a mouse model of bacterial pneumonia. While current work centers on ex vivo analyses of human neutrophils, mouse neutrophils, and mouse models of bacterial pneumonia and lung injury, we plan to begin studies of mitochondrial metabolism in neutrophils isolated from persons with pneumonia, sepsis, and acute respiratory distress syndrome.
Brief PI Description:
I am a physician-scientist with a clinical focus in critical care medicine and a scientific focus in host-pathogen interactions and neutrophilic responses in the lung. Our lab is funded by an NIH R01 award and from the Cystic Fibrosis Foundation.
JOB DESCRIPTION:
MINIMUM QUALIFICATIONS:
NOTE: Applicants applying with a M.D. or equivalent degree must be eligible for a Georgia medical license to meet the minimum qualifications.
NOTE: Position tasks are generally required to be performed in-person at an Emory University location. Remote work from home day options may be granted at department discretion. Emory reserves the right to change remote work status with notice to employee.
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