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The aim of the project is the adaptation and validation of the πCIT algorithm for the pediatric population by accounting for significant differences in AML biology and treatment between children and adults. The current model is written in gPROMS, a SIEMENS programming language for simulation, optimization and parameter estimation; and describes proliferation, differentiation and maturation processes of normal haematopoietic cells and leukemic sub-clonal populations in the bone marrow, and migration of normal mature cells and leukemic cells into peripheral blood. The project builds on current work in the BSEL and spin-off start-up company of Dr. Mantalaris, Dr. Panoskaltsis and Dr. Quiroga.
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