Emory

Principal Development Scientist

Job Number
88205
Job Type
Regular Full-Time
Division
Emory College
Department
ECAS: Chemistry
This position may involve the following Health and Safety issues:
Not Applicable
Job Category
Laboratory
Campus Location (For Posting) : City
Atlanta
Location : Name
Emory Campus-Clifton Corridor

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Emory University is a leading research university that fosters excellence and attracts world-class talent to innovate today and prepare leaders for the future. We welcome candidates who can contribute to the diversity and excellence of our academic community.

Description

The Liotta Research Group (LRG) is an Emory-based medicinal chemistry and drug discovery research group, led by Dr. Dennis Liotta. Our focus is the discovery and development of novel therapeutic agents. The drugs, generated by the LRG over several decades, include therapies for HIV, hepatitis B (HBV), cancer and neurological disorders, to name a few. In addition to our ongoing programs in antivirals and prodrug platform technologies, our current efforts include designing and developing novel non-opioid analgesics, anti-anxiolytics, NMDA receptor modulators, chemotherapeutics and immuno-oncology agents.

 

The Role:

We are seeking a highly motivated Bioanalytical/DMPK professional for our medicinal and synthetic chemistry group. They are expected to perform duties with a high degree of independence, initiative and judgment. The project(s) will focus on the design, validation and execution of in vitro biochemical experiments to determine the biodistribution, pharmacodynamic properties and efficacy of compounds in preclinical studies. They will lead the in vitro and in vivo profiling of novel therapeutic agents to prepare such compounds to meet key development objectives and milestones. Furthermore, interested individuals must also be motivated to prepare key research results and findings for peer-review publications, oral presentations and patent applications. A successful applicant will lead our bioanalytical team and support the research of our multidisciplinary group in the discovery and development of novel therapeutic agents.

 

JOB DESCRIPTION:

  • Functions as the Principal Investigator or Co-Principal Investigator for the Emory Institute for Drug Development (EIDD) or the Liotta Research Group.
  • Exercises primary authority over the conduct of projects, including protocol development and adherence.
  • Oversees large, often multidisciplinary, research and development projects; works closely with department or center heads on long-range planning.
  • May serve as lead scientist of a defined research and development project, or as an interstitial member of a research team.
  • Assumes responsibility for direct reports including recruiting, managing, mentoring and developing scientific staff.
  • Oversees fiscal matters with respect to cost of experiments, technology, external collaborations, and travel.
  • May submit protocol proposals to Emory IACUC, and upon approval, have access to Emory vivaria.
  • Publishes original and innovative findings.
  • May participate in scientific societies, committees, and review groups at the national and international level.
  • Performs other related duties as required.

ADDITIONAL JOB DETAILS:

  • Design, validation, and implementation of rigorous assays from cells and tissues. 
  • Strategically design and lead ADME, PK and PD studies, critically analyze and interpret data, identify issues and help overcome experimental challenges.
  • Extract and analyze the samples to determine its half-life, and metabolites using LC/MS/MS.
  • Analyze, interpret, summarize and communicate scientific data to the project teams promptly.
  • Lead the design of in vivo, preclinical PK/PD experiments to advance therapeutic projects.
  • Oversee external assay performance and method transfer with CROs.
  • Mentor and/or manage bioanalytical scientists and chemist.
  • Collaborates extensively with multiple project teams across scientific disciplines and will possess excellent organizational and personal interaction skills.
  • Strategically prioritize programs with respect to opportunity, risk and resource needs.
  • Communicate with stakeholders regarding project advancement and study plans.
  • Devises highly specialized research procedures by applying knowledge of advanced research techniques to new assays.
  • Ensure lab instruments remain calibrated and in good working condition.
  • Ability to adapt and exercise flexibility for changing platform needs, workflows and projects.
  • Strong oral and written communication skills are essential.

  PREFERRED QUALIFICATIONS: 

  • Proficiency in handling biological matrices, including human and mouse liver microsomes, and plasma, etc. 
  • Hands-on knowledge of LC-MS/MS. Experience with Agilent instruments including ChemStation or MassHunter is preferred but not required.
  • Trains research staff in specialized procedures and theoretical concepts for exceptional tests.
  • Proficiency with software such as GraphPad Prism, Microsoft Office, etc. for data analysis and figure generation.
  • Attention to detail with excellent organizational, experimental data recording and time management skills.
  • Ability to develop and improve new skill sets and knowledge necessary to successfully support research projects.
  • Ability to interact effectively with team members and function collaboratively in a highly productive, and dynamic environment.

MINIMUM QUALIFICATIONS:

  • Ph.D., M.D., or equivalent plus ten years of professional research experience.
  • Experience directing multiple scientific projects and in supervising research and development staff is preferred.

NOTE: Position tasks are generally required to be performed in-person at an Emory University location.  Remote work from home day options may be granted at department discretion. Emory reserves the right to change remote work status with notice to employee.

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